Son dönemde yapılan araştırmalarda en mutlu şehir olarak seçilen Sinop’un yüzyıllar öncesinde bir sakini vardı ki insanlık için mutlu olmanın doğru yolunu bulmayı kendine dert edinmişti. Öğretileri Roma İmparatorluğu’nun resmi dini gibi benimsenecek, Marcus Aurelius gibi Roma Krallarının filozofu olmaktan gurur duyacağı Stoa Okulunun ve Dünya Hükümdarı Büyük İskender’in büyük övgüsüne mazhar olmuş, Sinoplu Diogenes.

Objective: to evaluate CANLPH score and systemic immune inflammation index (SII) in patients with symptomatic rheumatic mitral stenosis (MS) undergoing percutaneous mitral balloon valvuloplasty (PMBV). -/- Methods: 62 patients who underwent PMBV in our clinic between 2018 and 2021 were included retrospectively. The patients were divided into 2 groups according to echo score. The CANLPH score was calculated from the cut-off values of C-reactive protein to albumin ratio (CAR), neutrophil to lymphocyte ratio (NLR) and platelet to hemoglobin ratio (PHR), determined (...) with the Youden index and SII by the formula platelet x neutrophil/lymphocyte. P <0.05 was considered statistically significant. -/- Results: The mean age of the patients was 44.5±10.4 years (40 female, 64.5%). The mean values of SII and CANLPH scores were higher in the Echo score >8 group (p <0.001, both). The mean mitral gradient before and after PMBV was 12.6±5.7mm Hg and 5.0±2.4 mm Hg, and the mean valve area was 1.12±0.27 cm2 and 1.85±0.29 cm2. A statistically significant and negative correlation was observed between the gradient decrease after the procedure and the CANLPH score and SII (r=-0.426, p=0.001 and r=-0.418, p=0.001, respectively). In receiver operating characteristic (ROC) curve analysis, it was concluded that the ability of CANPLH score to predict the higher Echo scores was noninferior to SII with an area under curve (AUC:0.820 (0.701-0.906) and AUC:0.786 (0.664-0.880), z statistics 0.576 and p=0.564. -/- Conclusion: SII and CANLPH scores are correlated with Echo score. A significant negative relationship was found with both biomarkers and gradient decrease after the PMBV. (shrink)

Objective: The measurement of international publication activities is one of the essential indicators used to evaluate the scientific development level of countries. Although many studies are using the bibliometric method in the literature, it is seen that there are very few bibliometric studies in the field of anatomy. This study aimed to analyze the articles bibliometrically which conducted by researchers at institutions from Turkey and indexed in Science Citation Index Expanded (SCI-E) of the Web of Science database in the category (...) of Anatomy and Morphology. Materials and Methods: According to 2019 data, journals in the Anatomy and Morphology category and indexed in the SCI-E were determined. Publications from Turkey that were published in these journals was determined. The full-texts of these articles were examined, and study types were defined. Also, VOSviewer software was used to create a collaboration and word co-occurrence network. Results: It was determined that there were 48,002 publications in 21 journals. It was found that 1,461 publications (3.04%) have at least one author from Turkey. The total number of citations was 11,728 for these publications. The average number of citations was 8.02±11.95. The radiological studies have increased statistically more than both experimental animal and cadaveric studies by years. In addition, it has been determined that the total number of articles, especially the radiological studies, has increased significantly over the years. Conclusion: The increase in the number of scientific studies in the field of anatomy is important in terms of the contribution of Turkey to literature in this area. (shrink)

Bu çalışmada, bitkibilimde kullanılan bir terim olan liken kelimesine, kök anlamına sadık kalarak Türkçe yeni bir karşılık önerilmektedir. Bu önerinin mantıksal çerçevesi, Antik Yunancadan, Orta Çağ Arapçasına, Orta Çağ Latincesine ve nihayetinde de Türkçeye kadar uzanan bir yelpazede, konuya esas teşkil eden tarihî metinlere ve onların kaydedildiği elyazmalarına dayanmaktadır. Türkçe metinlerde liken terimi yerine yalaç teriminin kullanımı öneri lmektedir. Bu öneri ülkemizdeki dilbilim, onomastik ve bitkibilim uzmanlarının eleştirel dikkatine sunulmaktadır.

Zihin–beden problemi felsefenin en köklü ve temel problemlerinden biridir. Köklü geçmişine rağmen probleme getirilen yanıtlar hususunda felsefe literatüründe bütünüyle bir uzlaşımın olmadığını söylemek ise pekâlâ mümkündür. Zihin–beden problemi en basit haliyle şöyle ifade edilebilir: Birbirinden her özelliği ile ayrılan zihin ve beden birbirlerini etkiler mi ve eğer etkiler ise bu etkileşim nasıl olmaktadır? Neredeyse her felsefi mesele gibi, zihin–beden probleminin geçmişi de Antik Grek felsefesine kadar götürülebilir. Ancak söz konusu problem ile ilgili yapılmış detaylı çalışmalar ilk olarak rasyonalist filozoflar tarafından (...) yapılmıştır ve daha sonra empirist felsefeye doğru genişlemiştir. Bu yazıda ilk kesim filozofların, yani rasyonalistlerin, problemi ortaya koyuş biçimleri ve söz konusu probleme getirmiş oldukları yaklaşımlar incelenecektir. Bunu yaparken dört temel rasyonalist filozofun argümanları analiz edilecektir. Daha detaylı bir ifadeyle, bu yazının konusu Descartes’ın, Malebranche’ın, Spinoza’nın ve Leibniz’in zihin–beden problemine sunmuş oldukları çözüm önerilerini incelemek olacaktır. Son kısımda ele almış olduğum dört filozofun felsefi pozisyonlarındaki farklılıklara kısaca değinilecek, zihin–beden probleminin çeşitli implikasyonları ele alınıp güncel felsefedeki problemler ile bağlantısı gösterilecektir. (shrink)

Felsefe tarihinin hiç şüphesiz en önemli filozoflarından biri olan Aristoteles (M.Ö. 384-322), aynı zamanda bilim tarihinin de en önemli kişilerindendir. Yaşadığı dönemde henüz bilim ve felsefe ayrılmamıştır; bununla birlikte Aristoteles, bilimsel ve sistemli düşünmenin, örnekleme yapmanın, bilim insanının doğaya öğrenmek için yaklaşmasının ilkelerini, ilk kez bu derece düzenli şekilde ortaya koyan kişi olmuştur. Dört neden kuramı söz konusu ilkelerin temelini oluşturmaktadır. Bu çalışmada günümüz biyolojisinin en kapsamlı tartışmalarından biri olan ‘fenotipin ne olduğu ve nasıl oluştuğu’ konusunun, Aristoteles’in dört neden kuramı (...) ile ilişkisi incelenmiştir. Genotip, fenotip ve çevrenin son derece karmaşık yolları içeren etkileşim ağı, araştırılması için birden fazla nedensel sorgulamayı gerektirir ki bu sorgulama bir anlamda Aristoteles’in dört neden kuramının, maddi, formel ve fail nedenlerinin bir arada sorgulanmasına benzerdir. (shrink)

Çevre sorunlarının katlanarak arttığı ve biyoloji biliminin büyük sıçramalarla geliştiği günümüzde organizma kavramının incelenmesi, hem kendi doğamızı (dolayısıyla da diğer canlılarla etkileşimlerimizi) hem de günümüz biyolojisindeki değişimleri daha iyi anlayabilmemiz için faydalı olacaktır. Bu çalışma, organizma kavramını özellikle organizma-çevre etkileşimi üzerinden inceleyerek günümüz biyolojisindeki önemini vurgulayacaktır. Organizma kavramı özellikle Modern Sentezden, Genişletilmiş Evrimsel Senteze geçişle birlikte ayrı bir önem kazanmıştır. Köklerini yirminci yüzyılın başlarındaki organizma-merkezci biyolojiden alan bu kavramın gelişimi, son birkaç on yıldır biyoloji biliminde gerçekleşmiş olan gelişmelerle (özellikle gelişim (...) biyolojisi, sistem biyolojisi ve ekoloji dallarında) iyice dinamikleşmiştir. Organizma kavramının gelişimini incelemek sadece biyoloji biliminin felsefesi açısından değil, bunun yanında, insan olarak kendi biyolojik varlığımızı -organizma- ve çevremizle (hem abiyotik hem de biyotik) olan etkileşimlerimizi, tekrar düşünmek açısından değerlidir. (shrink)

From the 1920’s onwards in Yozgat and its vicinity in the interior of Asia Minor field surveys and excavations have been increasingly undertaken. One recent project is an archaeological survey of the whole province of Yozgat which began in 2017 with the participation of many academics from different universities and disciplines. Through this survey, which covers a large area, research in just a few regions has been completed. In this article, seventeen Christian epitaphs discovered at and around the village of (...) Güneşli (east of Tavium), Aydıncık, Basilika Therma (Sarıkaya) and Çayıralan, mostly dating from the Vth–VIth centuries A.D. are presented. Three of them are fragmentary and a few are badly damaged. A carved bilingual Latin/Greek inscription records the «running» metaphor frequently employed by the Apostle Paul, all the other inscriptions introduced are Greek. There are interesting differences and analogies for the motifs on these gravestones and for the formulas employed in the epitaphs within the surrounding region. ****** Yozgat İlinden Yeni Hıristiyan Mezar Yazıtları Yozgat ve çevresindeki arkeoloji yüzey araştırmaları ve kazılar çalışmaları 1920’li yıllardan itibaren artış göstererek devam etmektedir. Bu bağlamda son projelerden bir tanesi de farklı üniversitelerden ve disiplinlerden pek çok akademisyenin katılımıyla 2017 yılında başlatılan ve Yozgat ilinin tamamını kapsayan arkeolojik yüzey araştırmalarıdır. Tüm il sınırlarını kapsayan bu araştırmadaki sistematik çalışmalar bazı bölgelerde tamamlanmış durumdadır. Makalede ise Güneşli Köyü, Aydıncık, Sarıkaya ve Çayıralan’da bulunan ve çoğunluğu MS V.–VI. yüzyıllara tarihlenen Hıristiyan mezar yazıtları tanıtılmaktadır. Yazıtlarının bir kısmı sadece fragman halinde ele geçmişken, bazıları ise oldukça tahrip olmuş durumdadır. Bunlardan birisinin üzerine, Aziz Paulus’un sıkça dile getirdiği «koşmak» metaforu Latince ve Yunanca çift dilli olarak kazınmıştır. Diğer yazıtların tamamı Yunancadır. Söz konusu mezar taşları üzerindeki betimlemelerin ve mezar yazıtlarındaki formüllerin bölgeler arasındaki farklılıkları ise ilgi çekicidir. Anahtar Sözcükler: Yozgat, Tavium, Hıristiyan Mezar Yazıtı, Koşucu, Aziz Paulus, Bizans Epigrafisi. (shrink)

Bu makalede Antalya Müzesi tarafından yürütülen 2016 yılı Perge kazıları kapsamında Batı Nekropo-lisi’nden ele geçen üç Hellence mezar yazıtı tanıtılmaktadır. MS II. yüzyılın sonu ile MS III. yüzyılın başına tarihlenen yazıtların ilk ikisi lahit, üçüncüsü ise bir mezar odası üzerinde yer almaktadır. Söz konusu belgeler öncelikli olarak mezarların uygunsuz kullanımı sonucunda tahsil edilecek olan ceza miktarları ile bu miktar-ların ödeneceği kasalara ilişkin yapılacak olan çalışmalarda bir veri oluşturabilecek niteliktedir. Ayrıca yazıt-larda yer alan kişilerin hem kent hem de bölgede nadiren görülen (...) ya da hiç karşılaşılmamış olan isimleri ise onomastik çalışmalara katkı sunacaktır. (shrink)

MS IV. yüzyılda yaşayan Decimus Magnus Ausonius, Roma İmparatorluğu'nun özellikle batı yakasını yakından tanıyan önemli bir alim ve devlet adamıydı. Onu mühim biri haline getiren en önemli husus; çeşitli bilimler özelindeki bilgi birikiminin derinliği yanında başarılı bir eğitmen olmasıydı. Ayrıca, son derece stratejik mevkilere erişebilmiş bir devlet adamıydı. Yaşamının son yıllarında kaleme aldığı şiirlerinden olan Ordo Urbium Nobilium, Geç Antikçağ dünyasına dair önemli veriler içermektedir. Bu kapsamda, söz konusu çalışma kendisinin özellikle coğrafya, tarih, filoloji ve Latin edebiyatı-kültürü gibi çeşitli alanlarda (...) Geç Antikçağ eğitim kurumlarının ders içeriğine dâhil edilmiş şiirini konu edinmektedir. Öyle ki, Ortaçağdan günümüze değin Ausonius’un neredeyse her eseri hakkında yüzlerce çalışma gerçekleştirilmiş ve bunların birçoğu da ya yayımlanmış ya da yayımlanmayı bekler niteliktedir. Bu makalenin kurgusu da; Ausonius'un Ordo Urbium Nobilium başlıklı şiirinin içeriğinin ve kapsamının değerlendirilmesine odaklanmaktadır. Bu değerlendirme bağlamında öncelikle şiirde bahsi geçen kentler, şiir içerisinde aktarılan özellikleriyle incelenmekte, ayrıca Ausonius'un bu yerleşim birimleriyle şahsi ve resmi münasabetlerinin eserindeki yansıması irdelenecektir. (shrink)

RESUMO A alimentação é o fator que mais onera um sistema de produção animal. Assim, a utilização de diferentes estratégias de alimentação dos animais ainda é o grande desafio da nutrição animal, principalmente, levando em consideração as exigências nutricionais de diferentes categorias de ruminantes, em especial bovinos em regiões tropicais, haja vista que a sazonalidade na produção de forragens afeta diretamente a produção bovina, promovendo inadequação no atendimento das exigências nutricionais dos animais principalmente em minerais e vitaminas. Uma alimentação que (...) não atenda as exigências nutricionais dos ruminantes gera prejuízos no sistema de produção, além de, em casos mais graves, ocasionar a perda do animal. Estudos que abordam o efeito e a importância de vitaminas e minerais na nutrição bovina são escassos e necessários. Recentemente a National Research Council (NRC) apresentou novos registros das exigências nutricionais das vitaminas e minerais. Essas alterações proporcionam um impacto econômico significativo em relação à nutrição animal. Nesse sentido, objetivou-se com esta revisão trazer informações acerca de vitaminas e minerais na nutrição de bovinos em pastejo. -/- Palavras-chave: Alimentação animal; forragem; pastagem; requerimentos nutricionais; ruminantes; vitaminas lipossolúveis (Source: AGROVOC). -/- ABSTRACT Animal feed is the factor that most burdens a production system. Thus, the use of different animal feeding strategies is still the great challenge of animal nutrition, taking into account the nutritional requirements of different categories of ruminants, especially cattle in tropical regions, given that seasonality in forage production directly affects cattle production, promoting inadequacy in meeting the nutritional requirements of animals, mainly in minerals and vitamins. A diet that does not meet the nutritional requirements of ruminants generates losses in the production system, in addition to, in more serious cases, causing the loss of the animal. Studies that address the effect and importance of vitamins and minerals in bovine nutrition are scarce and necessary. Recently the National Research Council (NRC) presented new records of the nutritional requirements of vitamins and minerals. These changes provide a significant economic impact on animal nutrition. In this sense, the objective of this review was to bring information about vitamins and minerals in the nutrition of grazing cattle. -/- Keywords: Animal feeding; fat soluble vitamins; forage; nutritional requirements; pasture feeding; ruminants (Source: AGROVOC). -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- 1. Cavalcanti CPL, Silva e Macedo TJ, Gois GC, Menezes VG, Monte APO, Silva AD, Silva DJM, Silva EO, Araújo GGL, Rodrigues RTS, Wischral A, Matos MHT, Queiroz MAA. 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A review of vitamin D and its importance to the health of dairy cattle. J Dairy Res. 2020; 87:84–87. 50. Alves EM, Pedreira MS, Santana CA, Silva FF. Nutrição vitamínica de vacas leiteiras. Pubvet. 2008; 2:1-17. 51. Jiang Q, Lin L, Xie F, Jin W, Zhu W, Wang M, et al. Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants. Microb. 2022; 10:1-16. 52. Magan JB, O’Callaghan TF, Zheng J, Zhang L, Mandal R, Hennessy D, et al. Effect of diet on the vitamin B profile of bovine milk-based protein ingredients. Foods. 2020; 9:1-17. 53. Pinedo LA, Berenchtein B, Selem ASMA. Estudo dos processos bioquímicos da fermentação, degradação e absorção de nutrientes dos alimentos em ruminantes. Pubvet. 2008; 2:1-10. 54. DA SILVA, Emanuel Isaque Cordeiro. Formulação e Avaliação de Suplemento Mineral Para Caprinos. Instrução Técnica Para o Produtor Rural de Pernambuco, v. 3, n. 1, p. 1-4, 2023. 55. DA SILVA, Emanuel Isaque Cordeiro. Nutrição Sobre a Reprodução e Fertilidade dos Bovinos. Emanuel Isaque Cordeiro da Silva, 2021. 56. DA SILVA, Emanuel Isaque Cordeiro. Suplementação e formulação de sal mineral e mistura múltipla para bovinos. Revista Universitária Brasileira, v. 2, n. 1, 2024. (shrink)

Bu araştırmanın amacı, öğretmen adaylarının bilimsel bilginin özelliklerine, önemine ve bilimin doğasına yönelik görüşlerini belirleyebilmektir. Araştırmanın çalışma grubunu, 2021-2022 öğretim yılında Hatay Mustafa Kemal Üniversitesi Eğitim Fakültesine bağlı Türkçe Öğretmenliği, Sınıf Öğretmenliği, Fen Bilgisi Öğretmenliği ve Özel Eğitim Öğretmenliği bölümlerinde okuyan öğretmen adayları oluşturmaktadır.

Bu çalışmada Metin Erksan’ın 1965 yapımı Sevmek Zamanı filminin “bir resme âşık olma” hikâyesi gibi görünen anlatısının aslında dönemin varoluşçu felsefesinin Türkiye’deki özgün bir yansıması olduğu ve bunun da filmdeki kadın karakter ile kurulduğu gösterilecektir. Yazıda filmde beliren temsil, korku, özgürlük ve iletişim temaları öncelikle Platon’un mağara alegorisi ve Heidegger’in varoluşçu felsefesinin Dasein (orada-varlık) kavramına başvurularak ele alınacaktır. Filmde âşık olduğunu söylemekten çekinen Halil’in Meral’in temsiline kaçışı resmin bakışındaki iyilik ve sevgi ile açıklanır. Doğada insanların uzağında yaşayan ve çalışan Halil (...) arkadaşı Mustafa’nın kötülük uyarısı ile Meral’den kaçmaktan vazgeçip onunla konuşmaya karar verir. Halil’in kaçışındaki korkunun kaynağı Halil’in varoluşunun Meral tarafından tanınıp onaylanmaması ihtimali olsa da Meral’in Halil’in varoluşuna özgürce ve ihtimamla yaklaşarak Halil’in korkusunu daha derin bir varoluşsal kaygı ve özgürlükle karşı karşıya getirir. Yazı Meral’in Halil ile aynı moda girebilip onu anlayabilmesi ve bu güce sahip olmasının ikisi arasında iletişimi mümkün kıldığını iddia etmektedir. Yazıda en son filmin toplumsal gerçekçi yanında kadın sorununun nasıl şekillendiği ortaya konulacaktır. Meral Halil’i tanısa, kendisi Halil tarafından tanınsa bile kendi sınıfından gelen bir tanıma reddi ile karşılaşmaktadır. Bu tanımamanın ölüm kadar sert bir şiddete ulaşmasının nedeni ise ekonomik sınıfı değil cinsiyetidir. (shrink)

Objective: Reference values have gained universal acceptance as the most powerful material that helps the decision-making-implementation process of the clinical laboratory. These values ​​may be affected by the geographical location, dietary habits, and other lifestyle changes of individuals applying to the clinical laboratory. Our study aims to determine the reference ranges for the biochemistry test panel, thyroid function tests, and insulin hormone levels, which are frequently needed by clinicians for the province of Gaziantep, with samples obtained from healthy individuals. -/- (...) Materials and Methods: In the study phase, the selection of reference individuals was carried out using the direct method a priori. For the study group, healthy individuals (224 men, 243 women) aged 18-45 were selected. Reference intervals (95% limit) were calculated according to the non-parametric method. -/- Results: When the reference intervals obtained in our study were compared with the reference intervals of the manufacturer, there were differences (> 10% lower or higher) in the upper and lower limits in urea (female and male), creatinine (male), HDL (female), AST (female and male), ALT (female), GGT (female), ALP (common), Lipase (common), CK (male), iron (male), TSH (female and male) markers. Male and female reference intervals for HDL, AST, ALT, and TSH differed significantly. Manufacturer reference ranges for these parameters were common to both sexes. -/- Conclusion: As a result, differences were determined between most of the reference intervals obtained in our study and the reference intervals we routinely use. We think the difference in the reference intervals is due to the differences in dietary habits and environmental factors. (shrink)

In 2001 soon after the Asian Crises of 1997-1998, the DotcomBubble, 9/11, the Enron crises triggered a fraud crisis in Wall Street that impacted the market to the core. Since then scandals such as the Lehman Brothers and WorldCom in 2007-2008 and the Great Recession have surpassed it, Enron still remains one of the most important cases of fraudulent accounting. In 2000’s even though the financial industry had become highly regulated, deregulation of the energy industry allowed companies to place bets (...) on future prices. At the peak of the dotcom bubble Enron was named as a star innovator but when the dotcom bubble burst, Enron’s plan to build high speed internet did not flourish and investors started to realize losses. Furthermore, the financial losses of the operations were hid using the market to market accounting technique instead of book value and using special purpose entities to hide debt. The root cause that was identified as a company with a toxic corporate culture focused on officer compensation rather than social responsibility and hence faulty leadership. Is it possible then that; ethical accounting practices, social responsibility and ethics all become inferior goods as income rises in an ‘irrationally exuberant’era? (shrink)

In this study, it is tried to put forth some explanations on the definition of vitality referring to the historical definition of biology that can be considered as thestudy of life. In accordance with the explanations, the necessity of revision and distinction of some terms in the contemporary biology is also mentioned. The first among which is the updating of the term known as homeostasis into homeokinesis. For this reason, a number of propositions are emphasized in order to clarify the (...) distinction of meaning. The following three questions were repeated in the process and structure of the article: 1) What is vitality? 2) Does it have any degrees or grades? 3) If so, what is the basic-vitality? In the search for an answer to these questions, different topics of biology are cited as references. At the same time, by claiming that vitality is an emergent process, it is proposed to follow the emergentist view, rather than the reductionist view on the statements of biological facts and phenomena. As a result, the cell level in the hierarchy of the biological organization is discussed first and a threefold-vitality view emergent in the levels of cell, organ and organism is put forth. Consciousness and memory are immanent in every level of the proposed threefold-vitality. -/- Keywords: Life, Cell, Homeokinesis, Consciousness. (shrink)

In this article, we propose the Fair Priority Model for COVID-19 vaccine distribution, and emphasize three fundamental values we believe should be considered when distributing a COVID-19 vaccine among countries: Benefiting people and limiting harm, prioritizing the disadvantaged, and equal moral concern for all individuals. The Priority Model addresses these values by focusing on mitigating three types of harms caused by COVID-19: death and permanent organ damage, indirect health consequences, such as health care system strain and stress, as well as (...) economic destruction. It proposes proceeding in three phases: the first addresses premature death, the second long-term health issues and economic harms, and the third aims to contain viral transmission fully and restore pre-pandemic activity. -/- To those who may deem an ethical framework irrelevant because of the belief that many countries will pursue "vaccine nationalism," we argue such a framework still has broad relevance. Reasonable national partiality would permit countries to focus on vaccine distribution within their borders up until the rate of transmission is below 1, at which point there would not be sufficient vaccine-preventable harm to justify retaining a vaccine. When a government reaches the limit of national partiality, it should release vaccines for other countries. -/- We also argue against two other recent proposals. Distributing a vaccine proportional to a country's population mistakenly assumes that equality requires treating differently situated countries identically. Prioritizing countries according to the number of front-line health care workers, the proportion of the population over 65, and the number of people with comorbidities within each country may exacerbate disadvantage and end up giving the vaccine in large part to wealthy nations. (shrink)

Machine learning algorithms may radically improve our ability to diagnose and treat disease. For moral, legal, and scientific reasons, it is essential that doctors and patients be able to understand and explain the predictions of these models. Scalable, customisable, and ethical solutions can be achieved by working together with relevant stakeholders, including patients, data scientists, and policy makers.

All parties involved in researching, developing, manufacturing, and distributing COVID-19 vaccines need guidance on their ethical obligations. We focus on pharmaceutical companies' obligations because their capacities to research, develop, manufacture, and distribute vaccines make them uniquely placed for stemming the pandemic. We argue that an ethical approach to COVID-19 vaccine production and distribution should satisfy four uncontroversial principles: optimising vaccine production, including development, testing, and manufacturing; fair distribution; sustainability; and accountability. All parties' obligations should be coordinated and mutually consistent. For (...) instance, companies should not be obligated to provide host countries with additional booster shots at the expense of fulfilling bilateral contracts with countries in which there are surges. Finally, any satisfactory approach should include mechanisms for assurance that all parties are honouring their obligations. This assurance enables countries, pharmaceutical companies, global organisations, and others to verify compliance with the chosen approach and protect ethically compliant stakeholders from being unfairly exploited by unethical behaviour of others. (shrink)

There is no doubt that custard apple diseases are among the important reasons that destroy the Custard Apple plant and its agricultural crops. This leads to obvious damage to these plants and they become inedible. Discovering these diseases is a good step to provide the appropriate and correct treatment. Determining the treatment with high accuracy depends on the method used to correctly diagnose the disease, expert systems can greatly help in avoiding damage to these plants. The expert system correctly diagnoses (...) Custard Apple disease to make it easier for farmers to find the right treatment based on the appropriate diagnosis. Objectives: A specialized syllable language system was established for the diagnosis of Custard Apple plant disease. (shrink)

The term biodiversity, also known as the diversity of life, is often used to mean the diversity of the living beings in the biosphere. By diversity of the living beings, it is meant mostly living things as individuals. In addition, it is possible to discuss the diversity of species, ecosystems, and hereditary characteristics. In this study, answers were sought to questions such as ‘Is biodiversity a value, can it be measured, what does it mean for our country and the world, (...) what is the lack or lack of biodiversity’. Thus, it was emphasized that biodiversity should be accepted as a value per se. In direct connection with biodiversity, it has been argued that ecosystems should be protected through a combination of intervening and non-intervening methods. In addition, by referring to the nature - culture dichotomy, nature's being the source of culture is underlined. It was mentioned that ecosystems should be protected in order to protect the number of species, and for this reason, intensive consumption of biosphere resources should be prevented. It has been argued that the point of distinction in conservation studies should be determined as ens viva, the concept of being alive. As a result, a proposal consisting of nine items has been put forth in order that it should be considered while drawing a possible roadmap. (shrink)

Biology –in its simplest definition– is a natural science that studies the living things. Philosophy of Biology, on the other hand, is the whole of conceptual analysis, synthesis and deductions that filters the scientific information being produced by biology, especially those of ‘life’ and ‘evolution’. In this study, the importance of the philosophy-science view of the famous philosopher Teoman Duralı, who passed away a year ago, will be mentioned in terms of contemporary biology and philosophy of biology. In doing this, (...) first of all, the historical relationship between the philosophy of biology and the philosophy of science will be revealed. Then having in consideration of the scope of the philosophy of biology, its relationship to the pure biology and to the history of biology will be mentioned. Then, Duralı’s philosophy-science view will be examined in terms of meaning and cause-effect relationships, thus both his contribution to the philosophy of biology literature in Turkish and his position will be pointed out. In conclusion, the use of the term biophilosophy, which concerns and connects two separate-but-adjoint flowing rivers ‘the philosophy’ and ‘the biology’, will be mentioned by pointing out why ‘biology for philosophy’ and why ‘philosophy for biology’ are important reciprocally. Finally, a declaration consisting a list of ten proposed items will be put forth. (shrink)

In this study, after a short introductory information on the etymology, origin, and transition of botanical knowledge in Medieval Islamic Civilisation, we made a comparison of illustrated botanical works in Maghreb and Masriq through two illustrated books. We studied on randomly selected illustrations from Kitab al- Hashaish at-Tibb li-Diskuridus al-Aynzarbi translated by Istefan ibn Basil & Hunayn ibn Ishaq from Dioscorides’ Materia Medica, and Kitab al-Adwiyat al-Mufradat of Abu Ja’far Ahmad al-Ghafiqi, the Andalusian physician, pharmacist, and herbalist. We made comparisons (...) on the illustrations of nine plants and one lichen, chosen from Codex Osler of al-Ghafiqi, and Codices Ayasofya of Istefan-Hunayn, with real photos of plants and lichen, via the methods used currently in the science-art of botanical illustration. With this «botanical illustrative method», we conclude that in the same century, the work of al-Ghafiqi has been copied in a more accurate way than that of Istefan-Hunayn translation. -/- تخصص هذه الدراسة - بعد تقديم معلومات تمهيدية موجزة عن علم أصل الكلمات، وأصول وتطور المعرفة النباتية في الحضارة الإسلامية في العصور الوسطى - للتحليل المقارن للمؤلفات في علم النبات المصور في المغرب والمشرق، من خلال كتابين مصورين. و لهذه الغاية، قمنا بتحليل سلسلة من الرسوم، إختيرت بشكل تلقائي، أُخذت من كتاب النباتات الطبية لصاحبه دِيُسوفُورِيدس، و من ترجمة ابن استيفان ابن باسل و حنين ابن إسحاق لدراسة المادة الطبية لديسوفوريدس، و من كتاب الأدوية البسيطة لأبو جعفر أحمد الغافقي، و هو طبيب و صيدلي و عشاب أندلسي. لقد أجرينا مقارنات لرسوم تسعة نباتات و أشنة وقع الإختيار عليها من كتاب أوسلر للغافقي و من كتب أياصوفيا لإستيفان و حنين، مع صور حقيقية لعينات من هذه الأنواع، باستخدام الطرق المطبقة في وقتنا الراهن في فن وعلم الرسوم النباتية. و بعد تطبيق هذا المنهج التصويري النباتي، نستطيع أن نخلص إلى أنه، و على الرغم من إنتاجها في نفس القرن، فإن نسخ رسوم الغافقي النباتية كانت أكثر دقة من تلك الموجودة في ترجمة استيفان - حنين. الكلمات المفتاحية دِيُسوفُورِيدس، الغافقي، تاريخ علم النبات، الأندلس -/- Este estudio –tras una breve información introductoria sobre etimología, orígenes y evolución del conocimiento botánico en la civilización islámica medieval– está dedicado a un análisis comparativo de los tratados botánicos ilustrados en el Magreb y en el Máshreq, a través de dos libros ilustrados. Para ello, hemos analizado una serie de ilustraciones, elegidas al azar, extraídas del Libro de plantas medicinales de Dioscórides por Anazarba, traducción de Istefan ibn Basil y Hunayn ibn Ishaq del tratado De materia medica de Dioscórides, y del Libro de los medicamentos simples de Abu Ya'far Ahmad al-Gafiqi, médico, farmacéutico y herbolario andalusí. Hemos llevado a cabo comparaciones de las ilustraciones de nueve plantas y un liquen, escogidos del códice Osler de al-Gafiqi y de los códices Ayasofya de Istefan-Hunayn, con fotografías reales de especímenes de dichas especies, acudiendo a los métodos aplicados actualmente en el arte y ciencia de la ilustración botánica. Tras este «método ilustrativo botánico», podemos concluir que, aunque llevadas a cabo en el mismo siglo, las copias de ilustraciones de al-Gafiqi han resultado más precisas que las de la traducción de Istefan-Hunayn. (shrink)

There is not a consensus on the definition of vitality or life yet. Therefore, there are hundreds of definitions and interpretations about life. A number of new or similar definitions have been added in the relevant literature year by year. From this point of view, in this study, it has been examined whether the words canlılık (vitality) and hayat (life) in Turkish can be used as terms equivalent to each other and it has been put forward that it would be (...) more correct to use them separately. The relationship between the parts of an organism’s hierarchy is reviewed, based on the relationships that the cell, as the place where vitality arises, establishes with its similars on the horizontal and with the lineage on the vertical. Based on all of these, a vitality design has been put forward. According to this theoretical design, life has a purpose to continue, and this is possible through an activity of manifestation through the reproduction and diversity of the living beings. It is suggested to use the term homeokinesis instead of homeostasis in order to describe the balance in the living things. Keywords: life, philosophy of biology, relationality, vitality. (shrink)

In the exploratory study reported here, we tested the efficacy of an intervention designed to train teenagers with Möbius syndrome (MS) to increase the use of alternative communication strategies (e.g., gestures) to compensate for their lack of facial expressivity. Specifically, we expected the intervention to increase the level of rapport experienced in social interactions by our participants. In addition, we aimed to identify the mechanisms responsible for any such increase in rapport. In the study, five teenagers with MS interacted with (...) three naïve participants without MS before the intervention, and with three different naïve participants without MS after the intervention. Rapport was assessed by self-report and by behavioral coders who rated videos of the interactions. Individual non-verbal behavior was assessed via behavioral coders, whereas verbal behavior was automatically extracted from the sound files. Alignment was assessed using cross recurrence quantification analysis and mixed-effects models. The results showed that observer-coded rapport was greater after the intervention, whereas self-reported rapport did not change significantly. Observer-coded gesture and expressivity increased in participants with and without MS, whereas overall linguistic alignment decreased. Fidgeting and repetitiveness of verbal behavior also decreased in both groups. In sum, the intervention may impact non-verbal and verbal behavior in participants with and without MS, increasing rapport as well as overall gesturing, while decreasing alignment. (shrink)

The debate between natural law and positivist law has been received much attention. Ronald Dworkin exposes the limitation of positivist law through the argument of hard cases. This argument is furthered strengthened when we apply the interpretation of Martin Luther King Jr and the voluntarist natural law tradition, and Lon Fuller’s ‘procedural view’ and the application of the ‘principles of legality’.

The reception of the translations of Aristotelian and pseudo-Aristotelian works at the University of Paris in the thirteenth century promoted a new understanding of the sciences as specialized fields of knowledge. The huge amount of translations required a new organization of knowledge, which included novel subjects and categories. Among these there is a very special case, namely the pseudo-Aristotelian De plantis, translated from Arabic into Latin and then back into Greek to be re-translated into Latin again. De plantis was included (...) in the new curriculum in Ripoll 109, and constituted the main source for botanical studies until the sixteenth century. Throughout this paper we will explore the reception and impact of De plantis in both the Arabic and the Latin traditions. We aim to show its foundational role in the development of botany as a theoretical discipline within the natural sciences. (shrink)

Air pollutants pose a threat to biodiversity throughout the world. This study was conducted to evaluate atmospheric element accumulation in Isparta city, including Gölcük Nature Park, located in the Western Mediterranean Region of Turkey. It is aimed to determine the air quality and potential pollutant sources in the region through lichen biomonitoring. Specimens of the epiphytic foliose lichen Physcia aipolia (Erh. ex Humb.) Fürnr. were sampled from 14 sites in the study area and analyzed by ICP-MS with reference material in (...) order to detect 11 trace elements; Al, As, Cd, Cr, Cu, Fe, Mn, Ni, Pb, V, and Zn. The spatial distribution of these airborne elements in the study area was mapped. The results showed that the elemental sequence in terms of average concentrations measured was as follows: Ni >Cr >V >Fe >As >Al >Zn >Cu> >Cd >Mn >Pb. The results of cluster analyses of the elemental data indicated that the 3 major contaminants in the urban area were Cr, Ni, and V, probably due to the extensive use of coal in heating facilities and gasoline in vehicles. P. aipolia specimens accumulated maximal concentrations of As, Cr, Fe, Ni, and V in the northern and the southeastern localities surrounding the city, while Cd, Pb were most abundant in the eastern edge of Gölcük Nature Park. The pollution in Isparta city with heavy metal is worse than expected, mostly due to the extensive use of coal as fossil fuel. In addition, it seems to be associated with the city's topographic and climatic characteristics, e.g. inversion effects. (shrink)

Lichens are included in the classification system of fungi and have been used in medicine, pharmacy and industry from antiquity to present day in the treatment of various diseases. In this study, Peri Hyles Iatrikes of Dioscorides has been investigated and evaluated from lichenological point of view. It is found that, Dioscorides mentions about medical properties and uses of probable Parmelia species such as P. saxatilis (L.) Ach or P. sulcata Taylor.

One of the most important thinkers of the twentieth century, Heidegger’s phenomenological investigation of existence, had a notable influence on the world of thought. In this work, two planes that fold over each other and present a holistic structure in Heidegger’s thought have been wended at the same time. The first of these is the investigation of the social possibility of Dasein's aspects, Heidegger's main problematic, through spatial conceptualizations such as space, place, closeness and distance; the second plane is the (...) reframing of Dasein's social aspects in the context of the concepts of 'dwelling' and 'construction'. This discussion also reveals the possibility of interaction between philosophy (ontic/ontological being, metaphysics, Dasein) and sociology (society, coexistence, social) in Heidegger's thought through the concepts of architectural discipline such as space, place, dwelling and building. All in all, it seems that the dwelling Heidegger built for Dasein offers a remarkable proposition to the social aspect of architecture; this points, above all, to the potential of “being with”, of human community, of a new relationship with the world. (shrink)

It is now widely accepted that astronomical factors trigger the emergence of glacial and interglacial periods. However, nearly two centuries ago, the overall situation was not as apparent as it is today. In this article, I briefly discuss the astronomical model of ice ages put forward in the 19th and early 20th centuries. This period was indeed anni mirabiles for scientists to understand the ice age phenomenon. Agassiz, Adhémar and Croll laid the foundation stones for understanding the dynamics of ice (...) ages. But it was Milankovitch who combined empirical geology with mathematical astronomy. Specifically, he identified the shortcomings of the preceding ice age models and modified his model accordingly. In what follows, I review earlier approaches to the ice age problem and show how they failed to meet their objectives. Next, I show how Milankovitch's model managed to capture all sufficient astronomical elements. The final sections focus on Milutin Milankovitch's successful approach, including his accomplishment of tackling the problem mathematically. (shrink)

The development of the Functional Genomics Investigation Ontology (FuGO) is a collaborative, international effort that will provide a resource for annotating functional genomics investigations, including the study design, protocols and instrumentation used, the data generated and the types of analysis performed on the data. FuGO will contain both terms that are universal to all functional genomics investigations and those that are domain specific. In this way, the ontology will serve as the “semantic glue” to provide a common understanding of data (...) from across these disparate data sources. In addition, FuGO will reference out to existing mature ontologies to avoid the need to duplicate these resources, and will do so in such a way as to enable their ease of use in annotation. This project is in the early stages of development; the paper will describe efforts to initiate the project, the scope and organization of the project, the work accomplished to date, and the challenges encountered, as well as future plans. (shrink)

Although ethics is an essential component of undergraduate medical education, research suggests current medical ethics curricula face considerable challenges in improving students’ ethical reasoning. This paper discusses these challenges and introduces a promising new mode of graduate and professional ethics instruction for overcoming them. We begin by describing common ethics curricula, focusing in particular on established problems with current approaches. Next, we describe a novel method of ethics education and assessment for medical students that we have devised, the Medical Ethics (...) Bowl. Finally, we suggest pedagogical advantages to MEBs when compared to other ethics curricula. (shrink)

Abstract: Lotteries have long been a source of fascination and intrigue, offering the tantalizing prospect of unexpected fortunes. In this research paper, we delve into the world of lottery predictions, employing cutting-edge AI techniques to unlock the secrets of lottery outcomes. Our dataset, obtained from Kaggle, comprises historical lottery draws, and our goal is to develop predictive models that can anticipate future winning numbers. This study explores the use of deep learning and time series analysis to achieve this elusive feat. (...) Through rigorous experimentation and data-driven approaches, we seek to determine the viability of AI in the realm of lottery predictions. Our findings reveal both the promise and limitations of AI in this context, shedding light on the complexities of lottery data and the potential need for quantum computing as a last resort. (shrink)

This paper attempts to rethink the philosophy of Muhammad Iqbal (1877–1938) and challenge the still prevailing tendency in Iqbal scholarship to view it merely as an outcome of the influence of the ideas of various Western/European philosophers. I present Iqbal’s arguments in their particular historical and intellectual context to show that they developed in response to a specific philosophical problem and that Iqbal looked for a solution to that problem in Islamic tradition. I suggest that Iqbal’s philosophy is best understood (...) in the context of, and as a response to, the problem of nihilism as it was debated in modern German philosophy during ‘the pantheism controversy’ in the eighteenth and nineteenth centuries. To demonstrate this, I analyse Iqbal’s article on ʿAbd al-Karīm al-Jīlī to show his concern with the problem of nihilism, and his solution to it based on al-Jīlī’s Sufism. (shrink)

Shortages of new therapeutics to treat coronavirus disease (COVID-19) have forced clinicians, public health officials, and health systems to grapple with difficult questions about how to fairly allocate potentially life-saving treatments when there are not enough for all patients in need (1). Shortages have occurred with remdesivir, tocilizumab, monoclonal antibodies, and the oral antiviral Paxlovid (2) -/- Ensuring equitable allocation is especially important in light of the disproportionate burden experienced during the COVID-19 pandemic by disadvantaged groups, including Black, Hispanic/Latino and (...) Indigenous communities, individuals with certain disabilities, and low-income persons. However, many health systems have resorted to first-come, first-served approaches to allocation, which tend to disadvantage individuals with barriers in access to care (3). There is mounting evidence of racial, ethnic, and socioeconomic disparities in access to medications for COVID-19 (4, 5). -/- One potential method to promote equitable allocation is to use a weighted lottery, which is an allocation strategy that gives all eligible patients a chance to receive the scarce treatment while also allowing the assignment of higher or lower chances according to other ethical considerations (6). We sought to assess the feasibility of implementing a weighted lottery to allocate scarce COVID-19 medications in a large U.S. health system and to determine whether the weighted lottery promotes equitable allocation. (shrink)

Traditionally, being a realist about something means believing in the independent existence of that something. In this line of thought, a scientific realist is someone who believes in the objective existence of the entities postulated by our best scientific theories. In metaphysical terms, what does that mean? In ontological terms, i.e., in terms of what exists, scientific realism can be understood as involving the adoption of a scientifically informed ontology. But according to some philosophers, a realistic attitude must go beyond (...) ontology. The way in which this requirement has been understood involves providing a metaphysics for the entities postulated by science, that is, answering questions about the nature of what ontology admits to exist. We discuss how two fashionable approaches face the challenge of providing a metaphysics for science: a form of naturalism and the Viking/Toolbox approach. Finally, we present a third way, which adopts the best of both approaches: the meta-Popperian method, which focuses on discarding the wrong alternatives, or better saying, the metaphysical profiles incompatible with certain theories. We present the meta-Popperian method, a metametaphysical method capable of objectively assessing which metaphysical profiles are incompatible with certain scientific theories. For this, we will use quantum mechanics as a case study, presenting some previously obtained results. As our focus is on methodological questions about the relationship between metaphysics and science; with this method, we can see how science can be used to avoid error in metaphysical issues. In our opinion, this would be a way to develop a productive relationship between science and metaphysics. (shrink)

In real-time, Twitter strongly imprints world events, popular culture, and the day-to-day; Twitter records an ever growing compendium of language use and change; and Twitter has been shown to enable certain kinds of prediction. Vitally, and absent from many standard corpora such as books and news archives, Twitter also encodes popularity and spreading through retweets. Here, we describe Storywrangler, an ongoing, day-scale curation of over 100 billion tweets containing around 1 trillion 1-grams from 2008 to 2020. For each day, we (...) break tweets into 1-, 2-, and 3-grams across 150+ languages, record usage frequencies, and generate Zipf distributions. We make the data set available through an interactive time series viewer, and as downloadable time series and daily distributions. We showcase a few examples of the many possible avenues of study we aim to enable including how social amplification can be visualized through ‘contagiograms’. (shrink)

This paper assesses the state of research ethics in low- and middle-income countries and the achievements of the Fogarty International Center's bioethics training program since 2000. The vision of FIC for the next decade of research ethics education is encapsulated in four proposed goals: (1) Ensure sufficient expertise in ethics review by having someone with long-term training on every high-workload REC; (2) Develop LMIC capacity to conduct original research on critical ethical issues by supporting doctoral and postdoctoral training and career (...) paths for research ethicists; (3) Make research training and review at LMIC institutions sustainable by identifying additional funding mechanisms and models; (4) Make institutional research systems more ethical and efficient through context-specific training integrated into all levels of scientific training. (shrink)

The article addresses the treatment given to the notion of subject in Slavoj Žižek and Robert Kurz. Without aiming at a synthesis between the two radically opposed positions, they are played against one another in order to reveal the unidimensional stances and false steps in the field of the constitution of the struggle for a concrete negation of capitalist society.

Psychopathy refers to a range of complex behaviors and personality traits, including callousness and antisocial behavior, typically studied in criminal populations. Recent studies have used self-reports to examine psychopathic traits among noncriminal samples. The goal of the current study was to examine the underlying factor structure of the Self-Report of Psychopathy Scale–Short Form (SRP-SF) across complementary samples and examine the impact of gender on factor structure. We examined the structure of the SRP-SF among 2,554 young adults from three undergraduate samples (...) and a high-risk young adult sample. Using confirmatory factor analysis, a four-correlated factor model and a four-bifactor model showed good fit to the data. Evidence of weak invariance was found for both models across gender. These findings highlight that the SRP-SF is a useful measure of low-level psychopathic traits in noncriminal samples, although the underlying factor structure may not fully translate across men and women. (shrink)

Due to how fast life moves these days, most parents forget to keep an eye on their children’s development and math skills as early as 4 years old. The role of child care is very important to enhance quality assurance practices among staff for the development of future leaders. The main objective of this study is to determine the strength of the relationships between each element and arithmetic proficiency among Malaysian TASKA children. This study is significant to identify the primary (...) factors that influence children’s math skills. A questionnaire was utilized to collect data. From 376 TASKAs registered in Malaysia, only 103 of the 458 selected centers provide care and instruction for children aged 36 to 48 months. Between the ages of 36 and 46 months, language, communication, and early reading skills account for the majority of a child’ s mathematical ability. Therefore, an effective training module should be built on these characteristics. The upcoming study will compare all unregistered TASKA facilities to the facilities that have been registered throughout Malaysia. (shrink)

I should like to offer my greatest thanks to Paul Griffiths for providing the opportunity for this exchange, and to commentators Gillian Brown, Steven Fuller, Stefan Linquist, and Erika Milam for their generous and thought-provoking comments. I shall do my best in this space to respond to some of their concerns.

Background. The COVID-19 pandemic necessitated drastic changes to undergraduate medical training at the University of Botswana (UB). To save the academic year when campus was locked down, the Department of Medical Education conducted a needs assessment to determine the readiness for emergency remote teaching (ERT) of the Faculty of Medicine, UB. Objectives. To report on the findings of needs assessment surveys to assess learner and teaching staff preparedness for fair and just ERT, as defined by philosopher John Rawls. Methods. Needs (...) assessment surveys were conducted using Office 365 Forms distributed via WhatsApp, targeting medical students and teaching staff during the 5 undergraduate years. Data were analysed quantitatively and qualitatively. Results. Ninety-two percent (266/289) of students and 73.5% (62/84) of teaching staff responded. Surveys revealed a high penetration of smartphones among students, but poor internet accessibility and affordability in homes. Some teaching staff also reported internet and device insufficiencies. Only WhatsApp was accessible to students and teaching staff. Conclusions. For equitable access to ERT in the future, the surveys revealed infrastructural improvement needs, including wider, stronger, affordable WiFi coverage within Botswana and enhanced digital infrastructures in educational institutions, with increased support for students. (shrink)